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Everything about Fosmid totally explainedFosmids are similar to cosmids but are based on the bacterial F-plasmid. The cloning vector is limited, as a host (usually E.coli) can only contain one fosmid molecule.
Low copy number offers higher stability than comparable high copy number cosmids. Fosmid system may be useful for constructing stable libraries from complex genomes. Fosmid clones were used to help assess the accuracy of the Public Human Genome Sequence.
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